Sucrose Malabsorption

Description

This is a simple, non–invasive, breath test that measures for sucrose malabsorption. This is a 3-hr long test with 7 breath samples collected (baseline and 1 every 30 minutes after drinking lactose solution).

Sucrose is a sugar found in fruits, and also known as table sugar is called disaccharides because it is composed of two simple sugars. Sucrose is typically broken down into glucose and fructose by the enzyme sucrase located in the brush border of the small intestinal mucosa. People with a congenital sucrase-isomaltase deficiency cannot break down the sugars sucrose and maltose, and other compounds made from these sugar molecules (carbohydrates).

Reduced enzymatic activity and villous atrophy in the small intestine are associated with maldigestive and malabsorptive diarrhea which can lead to sucrose malabsorption. More than 25 mutations within the human sucrase gene are responsible for sucrose malabsorption. Sucrose malabsorption can lead to dehydration, metabolic acidosis, hypercalcemia, failure to thrive, and developmental delay. The level of sucrase activity in the brush border can be used as a measure of small intestinal mucosal health.

Requirements

Preparation diet (1-2 days) and a 12-hr fast are required.

Time Allowed for Collection

3 Hours

Turn Around Time

1-2 business days (once the specimen is received by a laboratory).

CPT Codes

Hydrogen 91065 Methane 91068

Additional Resources

Patient Videos and Instructions

Download Collection Instructions

Sucrose Spec Sheet

Return Policy

All test sales are final. Returns may be allowed on a case-by-case basis with no test refundable 30-days of sale.  A $20.00 restocking fee will be assessed for all canceled orders once Neurovanna receives the returned, unused test collection materials. Used collection materials are not returnable.

Quality Control

Neurovanna’s quality control exceeds laboratory equipment manufacture’s recommendations with machinery calibrated after every 2-hrs or 5th test run. Testing performed on a CLIA waived, QuinTron BreathTracker TM Digital MicroLyzer H+. A parallel measurement of carbon dioxide (CO2) is obtained with each sample to allow for greater testing precision. All samples are processed using CO2 correction factor technique that reduces errors and improves interpretation.

Allergy/ Medical Warning

None.